2/15/2023 0 Comments Enzyme software kinetics![]() This subject is based on the well-known Michaelis–Menten model that describes the dynamics of enzyme-catalysed reactions (Henri, 1903 Johnson, & Goody, 1913) and the subsequent development in the case of allosteric enzymes showing cooperativity (Koshland, Némethy, & Filmer, 1966 Monod, Wyman, & Changeux, 1965). These range from the development of genetic techniques to produce artificially modified enzymes, where the precise determination of kinetic parameters is critical to quantifying small differences in activity between mutant forms, to the development of new drugs and pesticides, to name just a few. In fact in the last decade, the topic of enzymology has become increasingly relevant in several active fields of research (Dick & Burns, 2011 Khosla, 2000 Murakami, Kikuchi, Hisaeda, & Hayashida, 1996). The teaching of enzyme kinetics has been a central, unavoidable part of biochemistry courses for almost 40 years. ![]()
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